How much lyrica can you take

Opioids are a type of drug that can cause these side effects. Tramadol is an example of an opioid medication that can cause respiratory depression and sedation. Taking Lyrica and tramadol together may increase your risk for severe side effects.

Lyrica can affect your central nervous system CNS. Your CNS is made up of your brain and spinal cord. Your spinal cord has nerves that your brain uses to send signals throughout your body. This may cause symptoms such as sedation severe sleepiness and respiratory depression. Your doctor may adjust the dosage of one or more of your medications, or they may have you try a different medication for your condition. Lyrica may interact with certain diabetes drugs called thiazolidinediones. Both thiazolidinediones and Lyrica can cause swelling in your hands, feet, and legs.

Taking Lyrica with thiazolidinediones may raise your risk for swelling, as well as weight gain. If you take these drugs together, your doctor will likely monitor you for any symptoms of swelling or unusual weight gain. Your doctor may adjust your dosage of Lyrica or the thiazolidinedione, or they may have you try a different drug to treat your condition. But you should still check with your doctor or pharmacist before using any of these products while taking Lyrica.

If you have any questions about eating certain foods with Lyrica, talk with your doctor. As with all medications, the cost of Lyrica can vary. To find current prices for Lyrica in your area, check out GoodRx. The cost you find on GoodRx. Keep in mind that you may be able to get a day supply of Lyrica. If approved by your insurance company, getting a day supply of the drug could reduce your number of trips to the pharmacy and help lower the cost.

Before approving coverage for Lyrica, your insurance company may require you to get prior authorization. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. The insurance company will review the prior authorization request and decide if the drug will be covered.

If you need financial support to pay for Lyrica, or if you need help understanding your insurance coverage, help is available. Pfizer Inc. Lyrica may be available through a mail-order pharmacy. If recommended by your doctor, you may be able to receive a day supply of Lyrica. This means there should be less of a concern about running out of the medication.

Some Medicare plans may help cover the cost of mail-order medications. Lyrica is available in a generic form called pregabalin. A generic drug is an exact copy of the active drug in a brand-name medication. And generics tend to cost less than brand-name drugs. To find out how the cost of pregabalin compares with the cost of Lyrica, visit GoodRx.

They may have a preference for one version or the other. In animal studies, pregnant rats and rabbits given Lyrica gave birth to offspring with issues such as low birth weight and problems with bone formation. Together, you can determine the best treatment for your condition.

Lyrica belongs to a class of drugs called AEDs. This information can be helpful for doctors and people considering using these drugs during pregnancy. To sign up or learn more, visit the registry website or call Animal studies showed that Lyrica made male rats less fertile, caused changes to their sperm, and led to problems in their offspring.

If you plan to conceive a child, be sure to talk with your doctor. This is because Lyrica passes into breast milk. You can also call the American Association of Poison Control Centers at or use their online tool. But if your symptoms are severe, call or your local emergency number, or go to the nearest emergency room right away. For treating seizures in either adults or children, Lyrica is only Food and Drug Administration FDA -approved for use with other seizure medications.

If you have questions about using Lyrica with other medications, talk with your doctor or pharmacist. It may be helpful to take your doses around mealtimes to help you remember to take them. This could affect how your body absorbs the medication, which may affect how it works. This could also raise your risk for side effects. If you have trouble swallowing Lyrica capsules, talk with your doctor or pharmacist. The liquid solution may be an option for you.

Or, your doctor may have you try a different treatment for your condition. Before taking Lyrica, talk with your doctor about your health history.

Lyrica may not be right for you if you have certain medical conditions or other factors affecting your health. These include:. When you get Lyrica from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. This date is typically 1 year from the date they dispensed the medication. The expiration date helps guarantee that the medication is effective during this time.

If you have unused medication that has gone past the expiration date, ask your pharmacist if you can still use it. How long a medication remains good can depend on many factors, including how and where you store it.

Avoid storing this medication in areas where it could get damp or wet, such as bathrooms. This helps prevent others, including children and pets, from taking the drug by accident. It also helps prevent the drug from harming the environment. This article provides several useful tips on medication disposal.

You can also ask your pharmacist for information about how to dispose of your medication. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date.

However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

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This can result in…. Lyrica pregabalin. Medically reviewed by Dena Westphalen, Pharm. What is Lyrica? Lyrica uses. Lyrica generic. Lyrica side effects. Lyrica dosage. Lyrica vs. Alternatives to Lyrica. Common questions about Lyrica. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine.

Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. If you miss a dose of the extended-release tablet after your evening meal, take it before bedtime after a snack.

If you miss the dose before bedtime, take it after your morning meal. If you do not take the dose the following morning, then take the next dose at your regular time after your evening meal.

Do not take 2 doses at the same time. Administration of each daily dose was divided into three equal doses three times a day dosing. The primary endpoint was the hour partial-onset seizure rate based on the comparison of the baseline video EEG to a repeat 48—72 hour video EEG performed at the end of 14 days of double-blind treatment.

Table 13 shows median baseline seizure rates, median percent change from baseline in seizure rates, and percent difference relative to placebo derived from the primary analysis model by dose.

The efficacy of LYRICA for management of fibromyalgia was established in one week, double-blind, placebo-controlled, multicenter study F1 and one six-month, randomized withdrawal study F2.

Studies F1 and F2 enrolled patients with a diagnosis of fibromyalgia using the American College of Rheumatology ACR criteria history of widespread pain for 3 months, and pain present at 11 or more of the 18 specific tender point sites.

The studies showed a reduction in pain by visual analog scale. Patients were enrolled with a minimum mean baseline pain score of greater than or equal to 4 on an point numeric pain rating scale and a score of greater than or equal to 40 mm on the mm pain visual analog scale VAS.

The baseline mean pain score in this trial was 6. Responders to placebo in an initial one-week run-in phase were not randomized into subsequent phases of the study. There was no evidence of a greater effect on pain scores of the mg daily dose than the mg daily dose, but there was evidence of dose-dependent adverse reactions [see Adverse Reactions 6. The results are summarized in Figure 9 and Table For various levels of improvement in pain intensity from baseline to study endpoint, Figure 9 shows the fraction of patients achieving that level of improvement.

The figure is cumulative. Patients were titrated during a 6-week open-label dose optimization phase to a total daily dose of mg, mg, or mg. Patients were treated for up to 6 months following randomization. Fifty-four percent of patients were able to titrate to an effective and tolerable dose of LYRICA during the 6-week open-label phase. When considering return of pain or withdrawal due to adverse events as loss of response LTR , treatment with LYRICA resulted in a longer time to loss of therapeutic response than treatment with placebo.

The efficacy of LYRICA for the management of neuropathic pain associated with spinal cord injury was established in two double-blind, placebo-controlled, multicenter studies. Patients were enrolled with neuropathic pain associated with spinal cord injury that persisted continuously for at least three months or with relapses and remissions for at least six months. Patients were allowed to take opioids, non-opioid analgesics, antiepileptic drugs, muscle relaxants, and antidepressant drugs if the dose was stable for 30 days prior to screening.

Patients were allowed to take acetaminophen and nonsteroidal anti-inflammatory drugs during the studies. The week study consisted of a 3-week dose adjustment phase and a 9-week dose maintenance phase.

The fraction of patients achieving various levels of improvement in pain intensity from baseline to Week 12 is presented in Figure Some patients experienced a decrease in pain as early as week 1, which persisted throughout the study. The week study consisted of a 4-week dose adjustment phase and a week dose maintenance phase. The fraction of patients achieving various levels of improvement in pain intensity from baseline to Week 16 is presented in Figure White, hard-gelatin capsule printed with black ink "Pfizer" on the cap, "PGN 25" on the body; available in:.

White, hard-gelatin capsule printed with black ink "Pfizer" on the cap, "PGN 50" and an ink band on the body, available in:. Orange, hard-gelatin capsule printed with black ink "Pfizer" on the cap, "PGN " on the body, available in:.

White hard gelatin capsule printed with black ink "Pfizer" on the cap, "PGN " on the body, available in:. Light orange hard gelatin capsule printed with black ink "Pfizer" on the cap, "PGN " on the body, available in:.

Advise patients that LYRICA may cause angioedema, with swelling of the face, mouth lip, gum, tongue and neck larynx and pharynx that can lead to life-threatening respiratory compromise. Advise patients that LYRICA has been associated with hypersensitivity reactions such as wheezing, dyspnea, rash, hives, and blisters. Patients, their caregivers, and families should be counseled that AEDs, including LYRICA, may increase the risk of suicidal thoughts and behavior and should be advised of the need to be alert for the emergence or worsening of symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts, behavior, or thoughts about self-harm.

Report behaviors of concern immediately to healthcare providers [see Warnings and Precautions 5. Inform patients about the risk of respiratory depression. Include information that the risk is greatest for those using concomitant central nervous system CNS depressants such as opioid analgesics or in those with underlying respiratory impairment.

Teach patients how to recognize respiratory depression and advise them to seek medical attention immediately if it occurs [see Warnings and Precautions 5. Inform patients who require concomitant treatment with central nervous system depressants such as opiates or benzodiazepines that they may experience additive CNS side effects, such as respiratory depression, somnolence, and dizziness [see Warnings and Precautions 5. Adverse Reactions with Abrupt or Rapid Discontinuation.

Abrupt or rapid discontinuation may result in increased seizure frequency in patients with seizure disorders, and insomnia, nausea, headache, anxiety, hyperhidrosis, or diarrhea [see Warnings and Precautions 5. Counsel patients if they miss a dose, they should take it as soon as they remember. If it is almost time for the next dose, they should skip the missed dose and take the next dose at their regularly scheduled time.

Instruct patients not to take two doses at the same time. Advise patients that concomitant treatment with LYRICA and a thiazolidinedione antidiabetic agent may lead to an additive effect on edema and weight gain. For patients with preexisting cardiac conditions, this may increase the risk of heart failure [see Warnings and Precautions 5. Inform patients that if changes in vision occur, they should notify their physician [see Warnings and Precautions 5.

Instruct patients to promptly report unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever [see Warnings and Precautions 5. Inform men being treated with LYRICA who plan to father a child of the potential risk of male-mediated teratogenicity. In preclinical studies in rats, pregabalin was associated with an increased risk of male-mediated teratogenicity.

The clinical significance of this finding is uncertain [see Nonclinical Toxicology Instruct diabetic patients to pay particular attention to skin integrity while being treated with LYRICA and to inform their healthcare provider about any sores or skin problems. Some animals treated with pregabalin developed skin ulcerations, although no increased incidence of skin lesions associated with LYRICA was observed in clinical trials [see Nonclinical Toxicology This product's labeling may have been updated.

For the most recent prescribing information, please visit www. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment. It is not known if LYRICA is safe and effective in people under 18 years of age for the treatment of fibromyalgia and neuropathic pain with diabetes, shingles, or spinal cord injury.

For the treatment of partial-onset seizures when taken together with other seizure medicines, it is not known if LYRICA is safe and effective in children under 1 month of age.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins or herbal supplements. Especially tell your healthcare provider if you take:. Know the medicines you take. Keep a list of them with you to show your healthcare provider and pharmacist each time you get a new medicine.

Do not start a new medicine without talking with your healthcare provider. Skin sores did not happen in studies in people. If you have diabetes, you should pay attention to your skin while taking LYRICA and tell your healthcare provider about any sores or skin problems.

For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. It may harm them. You can ask your healthcare provider or pharmacist for information about LYRICA that is written for health professionals. Capsule shell: gelatin and titanium dioxide; Orange capsule shell: red iron oxide; White capsule shell: sodium lauryl sulfate, colloidal silicon dioxide.

LYRICA oral solution: methylparaben, propylparaben, monobasic sodium phosphate anhydrous, dibasic sodium phosphate anhydrous, sucralose, artificial strawberry and purified water. Approval: For partial-onset seizure dosing in pediatric patients 1 month of age and older, refer to section 2.

Fibromyalgia 2. Dose should be adjusted in adult patients with reduced renal function. Monitor patients and adjust dosage as appropriate. Advise of potential risk to the fetus. Table 1. Table 3 shows absolute and relative risk by indication for all evaluated AEDs. Table 3. Table 4. Table 5. Table 6. Table 7. Includes patients less than 30 kg for whom dose was adjusted to 3. Gastrointestinal disorders Salivary hypersecretion 1 4 2 0 Investigations Weight increased 4 13 8 4 Metabolism and nutrition disorders Increased appetite 7 10 8 4 Nervous system disorders Somnolence 17 26 21 Table 8.

Table 9. Table Comparison of Gender and Race The overall adverse event profile of pregabalin was similar between women and men. Data A pharmacokinetic study in ten lactating women, who were at least 12 weeks postpartum, evaluated the concentrations of pregabalin in plasma and breast milk.

Fibromyalgia Safety and effectiveness in pediatric patients have not been established. Adjunctive Therapy for Partial-Onset Seizures Safety and effectiveness in pediatric patients below the age of 1 month have not been established. Metabolism and Elimination Pregabalin undergoes negligible metabolism in humans.

Pharmacokinetics in Specific Populations Race In population pharmacokinetic analyses of the clinical studies in various populations, the pharmacokinetics of LYRICA were not significantly affected by race Caucasians, Blacks, and Hispanics. Gender Population pharmacokinetic analyses of the clinical studies showed that the relationship between daily dose and LYRICA drug exposure is similar between genders.

Renal Impairment and Hemodialysis Pregabalin clearance is nearly proportional to creatinine clearance CLcr. Elderly Pregabalin oral clearance tended to decrease with increasing age. Pediatric Pharmacokinetics Pediatric Patients 3 months to less than 17 years of age Pregabalin pharmacokinetics were evaluated in pediatric patients 3 months to less than 17 years of age with partial-onset seizures at dose levels of 2.

In Vivo Studies The drug interaction studies described in this section were conducted in healthy adults, and across various patient populations. Gabapentin The pharmacokinetic interactions of pregabalin and gabapentin were investigated in 12 healthy subjects following concomitant single-dose administration of mg pregabalin and mg gabapentin and in 18 healthy subjects following concomitant multiple-dose administration of mg pregabalin every 8 hours and mg gabapentin every 8 hours. Lorazepam Multiple-dose administration of pregabalin mg twice a day in healthy subjects had no effect on the rate and extent of lorazepam single-dose pharmacokinetics and single-dose administration of lorazepam 1 mg had no effect on the steady-state pharmacokinetics of pregabalin.

Oxycodone Multiple-dose administration of pregabalin mg twice a day in healthy subjects had no effect on the rate and extent of oxycodone single-dose pharmacokinetics. Ethanol Multiple-dose administration of pregabalin mg twice a day in healthy subjects had no effect on the rate and extent of ethanol single-dose pharmacokinetics and single-dose administration of ethanol 0.

If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine. Do not drive yourself — get someone else to drive you or call for an ambulance. If you need to go to hospital, take the pregabalin packet or leaflet inside it plus any remaining medicine with you. Like all medicines, pregabalin can cause side effects although not everyone gets them.

These common side effects may happen in more than 1 in people. They are usually mild and go away by themselves. Keep taking the medicine but tell your doctor if they bother you or don't go away:. If you have diabetes , pregabalin can upset your blood sugar control. Monitor your blood sugar more often for the first few weeks of treatment with pregabalin and adjust your diabetes treatment if you need to.

Talk to your doctor or diabetes nurse if you want more advice on what to do. Very few people taking pregabalin have serious problems. Call a doctor straight away if you get:. In rare cases, it's possible to have a serious allergic reaction anaphylaxis to pregabalin. These are not all the side effects of pregabalin. For a full list see the leaflet inside your medicines packet.

There is no clear evidence that pregabalin is harmful to an unborn baby but for safety you're usually only advised to take it in pregnancy if the benefits outweigh the risks. If you take pregabalin for epilepsy and become pregnant, do not stop the medicine without talking to your doctor first.

It's very important that epilepsy is treated during pregnancy as seizures can harm you and your unborn baby. If you're trying to get pregnant or have become pregnant, you're routinely recommended to take at least mcg of a vitamin called folic acid every day. It helps the unborn baby grow normally.

Pregnant women who take pregabalin are recommended to take a higher dose of folic acid. Your doctor might prescribe a high dose of folic acid 5mg a day for you to take during the first 12 weeks of pregnancy.

If you take pregabalin around the time of giving birth, your baby may need extra monitoring for a few days after they're born. This is because they may have pregabalin withdrawal symptoms. Tiny amounts of pregabalin can get into breast milk, but it's not clear whether it can harm the baby.

Talk to your doctor, as other drugs might be better while you're breastfeeding. For safety, tell your doctor if you're taking these medicines before you start pregabalin:. There are no known problems with taking herbal remedies and supplements with pregabalin. Tell your doctor or pharmacist if you're taking any other medicines, including herbal medicines, vitamins or supplements.

In epilepsy, it's thought that it stops seizures by reducing the abnormal electrical activity in the brain. With nerve pain, it's thought to block pain by interfering with pain messages travelling through the brain and down the spine.

In anxiety, it's thought that it stops your brain from releasing the chemicals that make you feel anxious. There's no evidence that pregabalin has lasting harmful effects, even if you take it for many months or years. Most people don't have to stay on the same brand of pregabalin as there is very little difference between brands. Talk to your doctor if you have been asked to switch to a different brand and you are worried about that.

If your epilepsy has been hard to control in the past and the brand you are now taking is working well for you, your doctor may recommend you stay on the same one. Some people have become addicted to pregabalin after taking it for a long time. If this happens, you will have withdrawal symptoms after you stop taking the medicine.

Talk to your doctor if you're concerned you are becoming physically dependant on pregabalin. If you have epilepsy, stopping pregabalin suddenly can cause seizures that will not stop. If you are taking it for any reason and stop suddenly, you may have a severe withdrawal syndrome. This can have unpleasant symptoms, including:.

It's possible to prevent withdrawal seizures and other symptoms by gradually reducing the dose of pregabalin. Do not stop taking pregabalin without talking to your doctor.